MarkMD

To find CNVs and other genetic markers associated with PD in a discovery sample of PD patients and a control sample
Replication of findings in a larger sample

Application of cutting-edge neuroimaging techniques and non-motor battery to study idiopathic PD patients with CNVs and other genetic markers conferring risk of PD in Tübingen.
Transfer of neuroimaging/clinical knowledge to Iceland and replication of studies in Iceland.
Identification of clinico-genetic subgroups of idiopathic PD by correlation of PD patients with specific genetic markers and neuroimaging/non-motor markers.

To investigate extrapyramidally healthy first degree relatives of PD patients for PD specific CNVs and other genetic markers. First degree relatives will be tested by neuroimaging and with the non-motor test battery to identify subjects at real risk for PD and in the long run estimate progression to clinical PD.
To look for CNVs and other genetic markers associated with PD in healthy subjects older than 50 who have been screened for pre-motor markers.

To compare and validate CNV findings in samples from Iceland and Germany
Application of EMG recording and novel neuroimaging techniques to ET patients/families in Tübingen.
Transfer of neuroimaging knowledge to Iceland and replication of studies in Icelandic ET families.